therapy has the advantage of other medcallons being give simullaneously (In PE co-msdcarions are ramovad Jointly with

0.4g/kg/day for 5 days. Effeciive In reding the disabillty in the disease 11 Combination therapy - In conkast to PE. IV Igtherapy has the advantage of other medcallons being give simullaneously (In PE co-msdcarions are ramovad Jointly with the exchange ) Hence [V]g therapy has been combined with high dose IV methylprednisolone (500 mg daily for 5 days) 12 Llquorpheresis (CSF miration] - is a technique to purity CSF from pathological laciare (probably responsible for manifestations of GBS) it has been postulated that pathological cellular or humoral lactars are concentrated in the CSF and these block sodium channels and hence liquorpherasis is altempled as a direct therapeutic intervantion Miller-F is her syndrome - & charaiieriaad by aphthalmplegia. ataxia and areflexia without weakness It s considered to be a varianl of GB ayntfome -i: nodes id ganglloslde GQ1 b are seen in 90% of 1patients Chronic Inflammatory demyelinatlng pofyneuropathy [CIDP) - is asubacute or ohm me progressive damy linallng neuropathy Progression over 2 months distinguishes it from G-B syndrome "the disorder is associated with increased frequency of HLA DR.3, Indicating that the disease may result from an aberrant immune response leading id a chronic form of G-B syndrome (III) Vasculatic neuropathies - In systemic disorders such as RA and PAN which produce a number -f different lesions within the nerve and are hence terrred multitocal Because of the multifocal onset, the comblnatioan of indivisual peripheral n involvement is called 'mononeuritis mulliplex'. Diagnosis -High ESR or positive antinuclear facter or aniinuclear cytoplasmlc antibody Nerve biopsy reveals patchy multifocal process IV Mutifocal motor nauropathy -resembles CIDP, but does not respond -well to steroite. It has considerable similarities to LMN form of MNO. aspecially becauae of marked fasciculations Disorder is suspected in patients that present with asymmetrical upper limb wasting in absence d sensory disturtance Diagnose - Evidence of conduction block often between supraclavicular fossa and axilla. (c) Elecirodiagnostic studies Evidence of nerve conduction slowing or block C Features making the dagnnsls doubtful 1 Warded paiabtent asymmetry of weakness . 2. Marked bladder or